This paper applies the orthogonal array with the grey relational analysis to optimize the printing machining parameters of light guide plate (LGP) considering the multiple performance characteristics. The application of grey relational analysis can convert the optimization of multiple performance characteristics into the optimization of a single performance characteristic. As a result, this technique can greatly simplify the optimization procedure of the complicated multiple performance characteristics. In this paper, the printing machining parameters, namely mixed rate of ink, velocity and pressure of printing process, and material and angle of scraper are optimized with considerations of multiple performance characteristics including illumination, homogeny, value of variance for the illumination and printing ink thickness. The experimental results using the optimal setting have obviously shown that the above performance characteristics in the printing process can be improved effectively together through this approach.